e-Guest Lecture : Leandro Soter

Nucleos(t)ides: Privileged Structures in the Search for Anticancer and Antiviral Compounds

Leandro Soter, professeur associé du département de chimie organique à l'Université Fédérale de Rio de Janeiro - Brésil, est actuellement fellow-in-residence à CY AS, invité du laboratoire BIOCIS

The nucleosides, as their phosphorylated derivatives, the nucleotides, are important molecules present in every cell and viral particles. This class of molecules participate in important cellular processes such as storage, transcription, and translation of genetic information, as well as signaling molecules.

Once these molecules play such important roles in life evolution and maintenance, since the 50’s they have been used as model compounds for developing analogues that would interfere in such processes. Over the following decades, the multidisciplinary efforts on studying the cell’s chemistry and biology allowed the improvement of strategies and of the rational design of new nucleos(t)ide analogues. Some of which were approved for the treatment of leukemias, gastric cancers and viral infections such as Herpes, AIDS, Hepatitis B and C.

The carboxamide nucleoside ribavirin is an important medicine, in clinical use, that presents the broader spectrum of antiviral activity. It was classified by the WHO as an essential medicine since 2007 and has been used for the treatment of HCV and different types of hemorrhagic fever infections. The recent development of ribavirin analogues with increased stability of the bond linking the base and the carbohydrate, allowed us to study new structures with unprecedent, substitution pattern while retaining its ability for base recognition.

Date : 6 mai 2021 de 12h30 à 14h00

La vidéo est publiée sur la chaîne YouTube de CY AS